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Wegovy (semaglutide) tablets are medications used for weight loss, long-term weight management, and to reduce the risk of major adverse CV events in certain patients with obesity or who are overweight.

Wegovy pill is an oral form of semaglutide that stimulates GLP-1 receptors in the brain to reduce hunger and slow stomach emptying, helping to achieve weight loss.

How does the Wegovy pill work?

The active ingredient in the Wegovy pill is semaglutide, a GLP-1 receptor agonist. GLP-1 is a hormone your body releases after eating that helps regulate appetite and manage blood sugar levels.

By mimicking the GLP-1 hormone, the Wegovy pill causes weight loss by:

-Reducing appetite and food cravings, helping you feel satiated with smaller portions of food.

-Slowing gastric emptying (the rate at which food leaves the stomach), which helps you feel fuller for longer after meals.

-Regulating blood sugar by increasing insulin secretion when glucose levels are high, preventing blood sugar spikes and food cravings.

How well does the Wegovy pill work?

In the OASIS 4 study, patients taking Wegovy tablets experienced an average weight loss of approximately 17% (16.6%), compared with 3% in the placebo group, after 64 weeks, when patients stayed on treatment. Regardless of treatment discontinuation, adults taking the Wegovy pill achieved an average weight loss of 13.6% (~14%), compared with 2.4% (~2%) in those receiving a placebo.

Who can use the Wegovy pill?

Wegovy pills are used for:

Long-term weight loss and weight management in:

adults with obesity.

adults who are overweight and  have a weight-related medical problem (e.g., blood pressure, type 2 diabetes, or high cholesterol)

To reduce the risk of major adverse CV events in:

adults with established CV disease and either obesity or overweight

How effective is the Wegovy pill?

In the Phase 3 OASIS-4 clinical trial, individuals taking 25mg of oral semaglutide daily for 64 weeks lost an average of 16.6% of their body weight. Around one in three participants also achieved 20% or more of body weight loss.

As well as body weight reduction, clinical trial findings also suggest improvements in health metrics commonly linked to being obese or overweight, such as blood sugar control and other markers associated with cardiovascular and metabolic health.

As with any weight management treatment, the weight loss results can vary based on starting weight, dose escalation, consistency with daily dosing, lifestyle changes and how well the medication is tolerated.

How do you take the Wegovy pill?

Wegovy pill should be taken once a day on an empty stomach with a small amount of water.

Avoid eating or drinking anything other than water or taking any other oral medication for at least 30 minutes after taking the Wegovy pill to avoid interfering with the absorption of the active ingredient from the pill.

Similar to Wegovy injectable pens, treatment typically begins at a lower dose that is gradually increased over time. This approach, known as dose titration, is designed to help your body adapt to the active ingredient and reduce the risk of experiencing side effects.

What is the difference between the Wegovy pill and the Wegovy injection?

The Wegovy pill and Wegovy injection both contain semaglutide. They work by activating GLP-1 receptors that help reduce appetite and increase feelings of fullness. However, there are differences in dosing, absorption and average weight-loss outcomes.

The Wegovy pill is a once-daily oral tablet, while the Wegovy injection is taken once weekly. Where injectable semaglutide is absorbed more consistently, clinical trials have shown that Wegovy injections generally lead to slightly greater average weight loss compared with oral semaglutide.

In studies, the Wegovy pill (oral semaglutide 25 mg) has been shown to produce average weight loss of around 16-17% over 64 weeks. Wegovy injections have demonstrated average weight loss of around 15-17%, with some patients achieving higher reductions depending on dose and duration of treatment.

The Wegovy pill offers a needle-free alternative and may suit those who prefer oral medication, while the injection provides the convenience of once-weekly dosing and more predictable absorption. Suitability depends on individual preference, response to treatment and clinical assessment.

Wegovy Side Effects

Common Wegovy side effects in adults may include:

Nausea (44%).
Diarrhea (30%).
Vomiting (24%).
Constipation (24%).
Stomach pain (20%)
Headache (14%).
Tiredness (11%).
Indigestion (9%)
Bloating (7%).
Burping (7%).
Low blood sugar in people with type 2 diabetes (6%).
Gas or flatulence (6%).
Gastroenteritis (6%).
Heartburn (5%).

These side effects occurred in 5% or more of obese or overweight adult patients using Wegovy 2.4mg in clinical trials. They usually subside within a few weeks of starting treatment or a few weeks after your dose increases.  These Wegovy side effects are usually mild and temporary and most likely will not interfere with long-term treatment. Some Wegovy patients (16%) stopped treatment due to side effects compared to 8% of placebo-treated patients in clinical trials.

Serious Side Effects

Wegovy can cause serious side effects, including pancreatitis, gallbladder disease, low blood sugar (hypoglycemia), kidney problems, serious allergic reactions, increased heart rate, suicidal thoughts or behavior, eye complications in type 2 diabetic patients (diabetic retinopathy), severe gastrointestinal side effects, and liquid or food getting into the lungs during deep sedation or anesthesia.

Allergic reaction – get emergency medical help if you have signs of an allergic reaction: hives, itching, dizziness, fast heartbeats, difficulty breathing, swelling of your face, lips, tongue, or throat.

You should call your doctor at once if you have symptoms of other serious Wegovy side effects, including:

Vision changes.
lass=”yoast-text-mark” />>Unusual mood changes, thoughts about hurting yourself.
>Pounding heartbeats or fluttering in your chest.
>A light-headed feeling, like you might pass out.
>Signs of a thyroid tumor – swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath.
>Symptoms of pancreatitis – severe pain in your upper stomach spreading to your back, nausea with or without vomiting. fast heart rate.
>Gallbladder problems – upper stomach pain, fever, clay-colored stools, jaundice (yellowing of the skin or eyes).
>Low blood sugar – headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery.
>Kidney problems – swelling, urinating less, feeling tired or short of breath, or
stomach flu symptoms – stomach cramps, vomiting, loss of appetite, diarrhea (may be watery or bloody).

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