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Bavencio (avelumab) is a prescription medication for certain cancers. It’s use for adults and children 12 and older with Merkel cell carcinoma (a type of skin cancer) that has spread.
It’s also for advance bladder and urinary tract cancer (urothelial carcinoma) that has spread or can’t be removed by surgery.
Additionally, Bavencio can be use with axitinib for advanced kidney cancer (renal cell carcinoma). Common side effects include tiredness, muscle and bone pain, and infusion reactions like chills and fever. Bavencio’s safety and effectiveness in children under 12 are not known.

How Does Bavencio Work?

Bavencio is a medication for treating certain cancers by boosting your immune system to fight cancer cells. However, it can sometimes cause your immune system to attack healthy organs and tissues, affecting their function.

Bavencio is a PD-L1 blocking antibody, which means it blocks a protein (PD-L1) that cancer cells use to hide from the immune system. By blocking this protein, Bavencio helps the immune system detect and attack cancer cells more effectively.

Dosage  and Usage

Bavencio can be injected by a healthcare provider or self-administered at home after proper training. Your doctor will determine the duration of treatment based on your response and any side effects you may experience.

Dosage Form and Strengths

Bavencio comes as an injection. Each vial contains 200 mg of the medication in 10 mL of solution, making it 20 mg/mL. The solution is clear and can range from colorless to slightly yellow.

Administration or Usage

Bavencio is administers by a healthcare provider through an intravenous (IV) line over 60 minutes. It is typically given every two weeks.

Patients are usually premedicated with an antihistamine and acetaminophen before the first four infusions to reduce the risk of infusion reactions.

The healthcare provider will monitor the patient with blood tests to check for side effects and decide the number of treatments needed. If a patient misses an appointment, they should contact their healthcare provider to reschedule as soon as possible.

Storage

Bavencio should be store in its original packaging to protect it from light. Keep it refrigerated at temperatures between 36°F to 46°F (2°C to 8°C). Do not freeze or shake the vial.

The solution is sterile, preservative-free, and ranges from clear and colorless to slightly yellow.

Each vial contains 200 mg of the medication in 10 mL (20 mg/mL) and is supplied as a single-dose vial. The vial stopper does not contain natural rubber latex.

Side Effects

Bavencio can cause side effects, some common and others more serious but rare. It is important to be aware of these potential side effects so you can monitor your health and report any issues to your healthcare provider.

Below are the common and serious but rare side effects associated with Bavencio.

Common Side Effects

Feeling tired
Muscle and bone pain
Infusion-related reactions (chills, fever, back pain)
Rash
Nausea
Constipation
Cough
Diarrhea
Urinary tract infection
High blood pressure
Mouth sores
Blisters or rash on the palms of your hands and soles of your feet
Hoarseness
Low levels of thyroid hormone
Liver problems
Stomach area pain
Headache

Serious but Rare Side Effects

Severe allergic reactions
Pneumonitis (inflammation of the lungs)
Colitis (inflammation of the colon)
Hepatitis (inflammation of the liver)
Endocrinopathies (hormone gland problems)
Nephritis (inflammation of the kidneys)
Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
Myocarditis (inflammation of the heart muscle)
Neurological toxicities (nerve problems)

If you experience any of these side effects, contact your doctor immediately.

How long does a Bavencio infusion take?

A Bavencio infusion takes 60 minutes. Your healthcare provider will administer Bavencio via IV infusion every 2 weeks. The infusion is given by a doctor or nurse in an infusion center, hospital, or doctor’s office.

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