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Ibrance treats HR-positive, HER2-negative advanced/metastatic breast cancer with aromatase inhibitors or fulvestrant. Also treats PIK3CA-mutated, endocrine-resistant breast cancer combined with inavolisib and fulvestrant after adjuvant therapy recurrence. It is taken once daily. Ibrance is not chemotherapy; it is a targeted treatment.

Ibrance is not recommended:

If you are allergic or have had an allergic reaction to Ibrance or ingredients in Ibrance
If you are pregnant or breastfeeding
For patients under 18 years of age

What are the Indications for Ibrance?

Ibrance is approved for the treatment of hormone receptor (HR) +, human epidermal growth factor receptor 2 (HER2), or metastatic breast cancer in male and female adult patients.

Ibrance is used in combination with other therapies, such as an aromatase inhibitor as initial endocrine-based therapy, or with fulvestrant in those whose disease has progressed after endocrine therapy.

How is Ibrance used?

Storage

Ibrance should be stored in the original package between 68°F and 77°F (20°C and 25°C) away from heat and moisture.
Keep out of reach of children.

Instruction

Take Ibrance by mouth, as directed by your doctor, with food at the same time every day. Swallow the capsule or tablet whole. Do not chew, split, or crush the capsule or tablet. Do not take any broken Ibrance capsule or tablet.

If you miss a dose, skip the missed dose and take your next dose as scheduled. If you threw up your dose, do not take another dose. Continue to take your next dose as scheduled.

Do not change your dosage and take more than what is prescribed, or stop using Ibrance without consulting your doctor. If you took more than prescribed, contact your doctor immediately or seek emergency medical care.

Dosage – Buy Ibrance online USA Authorized Pharmacy

Ibrance is available in both capsule and tablet formulations at 75 mg, 100 mg, and 125 mg strengths. Capsules and tablets are not interchangeable on a mg-to-mg basis due to differences in formulation. Ibrance treatment is taken in a 28-day cycle. The recommended starting dose is 125 mg once daily for 21 days with 7 days off for a total of 28 days.

Side Effects

It’s important to understand that although Ibrance is FDA approved, it comes with side effects that may or may not affect you.

Before starting Ibrance, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts to Ibrance, side effects may go away. Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own.

Nausea
Dizziness.
Vomiting
Anxiety.
Constipation.
Rash
Loss of appetite.
Hair thinning or loss.
Sore mouth.
Tiredness.

Serious Side Effects

Severe adverse reactions while taking Ibrance may occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.

Low white blood cell counts (neutropenia): weakness, dizziness, shortness of breath, bleeding easily, bruising easily, or nosebleeds.
Infections
Lung problems: chest pain, cough, shortness of breath, or trouble breathing.

What are the ingredients in Ibrance?

Ibrance contains the active ingredient palbociclib. In capsule form, Ibrance contains the inactive ingredients: microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and hard gelatin capsule shells. The light orange, light orange/caramel, and caramel opaque capsule shells contain gelatin, red iron oxide, yellow iron oxide, and titanium dioxide. The printing ink contains shellac, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone. In tablet form, Ibrance contains the inactive ingredients: microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate, succinic acid, HPMC 2910/hypromellose, titanium dioxide, triacetin, and FD&C Blue #2/Indigo Carmine Aluminum Lake. In addition, the 75 mg and 125 mg tablets contain red iron oxide and the 100 mg tablets contain yellow iron oxide.

What form is Ibrance available in?

Ibrance is available in capsule or tablet forms.

Who should not use Ibrance?

Ibrance should not be used if you are allergic to Ibrance or any ingredients in Ibrance, in pediatric patients, or if you are pregnant or breastfeeding. Serious allergic reactions include severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.

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