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Bosulif (bosutinib) is a protein tyrosine kinase inhibitor medication use for the treatment of the blood cancer known as Philadelphia chromosome-positive chronic myelogenous leukemia, or Ph+ CML. This medication is typically use in those who have just been newly diagnose with this condition or those will not benefit from other types of therapy before trying Bosulif.

How is Bosulif Use?

Bosulif is available in tablet form and should be taken once per day with food, every day. Bosulif tablets should be swallowed whole and not chewed, split, or crushed for any reason.

It is either used as the first line of treatment for Ph+ CML or used as an alternative treatment for the same condition when other types of therapies have failed to be effective for the patient.

Storage

This medication should be store at room temperature, in the range of 68°F (20°C) and 77°F (25°C). If a patient is traveling or the medication otherwise needs to be transported for any reason, it may be expose to temperatures no lower than 59°F (15°C) and 86°F (30°C).
Keep this medication out of the reach of children at all times.
Do not touch this medication if it breaks.

As an anticancer medication, there are special circumstances regarding the disposal of Bosulif. Due to the risks associated with this type of medication, it is strongly recommended that patients simply return any unused Bosulif to their doctor or their doctor’s practice for safe disposal. Bosulif should never be flushed or thrown away in household trash.

Uses

Bosulif is prescribed for the treatment of Philadelphia chromosome-positive chronic myelogenous leukemia, also referred to as Ph+ CML.

How Does Bosulif Work?

This medication is a tyrosine kinase inhibitor (TKI). The enzyme known as BCR-ABL kinase encourages the development and worsening of CML, and Bosulif functions by inhibiting this enzyme. It is capable of inhibiting 16 of the 18 current forms that exist of BCR-ABL kinase, making it incredibly effective at treating this component of CML.

Dosage

Bosulif is available as a tablet that is taken orally once per day, every day, with food. It comes in the following strengths:

100 mg
400 mg
500 mg

The dosage that a patient will be required to take for treatment depends on their current medical status. Based on their current overall health, their age, whether they are new to using this type of medication or have previously tried other types of treatment before beginning Bosulif, any other medications they may be taking, and the severity of their current condition for which Bosulif has been described, their doctor will advise them on the appropriate dosage and may adjust the dosage later on as needed.

Patients should take the medication exactly as prescribed by their doctor. Commonly, most patients begin taking a lower dosage of Bosulif to begin with and often have that dosage increase over time.

Individuals with a new diagnosis of Ph+ CML that have not receive any prior forms of treatment for the condition are generally started on a daily dose of 400 mg.

Those who have previously received other forms of treatment for Ph+ CML that prove to be ineffective or have problematic side effects are most commonly prescribe the 500 mg strength of this medication to be taken once per day.

For those who have blood, kidney, or liver disorders, these conditions may also require adjustment of the dosage by the patient’s prescribing physician. Changes to dosage may also be made if an individual has significant side effects or if treatment with the current strength of the medication becomes ineffective.

The maximum dosage of Bosulif a patient may take per day is 600 mg.

Overdose

Individuals who have overdose on this medication have reported no serious adverse reactions from consuming excessive amounts of this medication. If you have taken too much Bosulif, you should contact your doctor or local Poison Control Center for further advice. Treatment for an overdose of this medication typically includes supportive treatment to manage the increased likelihood of side effects already associated with the medication as well as an observation period to ensure there are no significant adverse effects of a high dosage of Bosulif within one’s system.

Side Effects

Bosulif is rank with a range of different side effects. Please consult with your physician if you experience any of the following symptoms.

The most common side effects of taking Bosulif are as follows:

Heart problems.
Stomach problems
Fluid retention.
Liver problems
Low blood cell counts.
Lidney problems

For individuals with newly diagnose chronic myelogenous leukemia that begin using Bosulif for treatment, the following side effects are most commonly experience in this particular group of patients using the medication:

Abdominal pain
Diarrhea
Nausea
Skin rash
Liver function test changes
Reduction of platelet counts

Patients who have begun using Bosulif for treatment of CML but have done so due to the need for a change in their treatment because prior medications and therapies were ineffective or not well-tolerated may experience a different set of side effects when using this medication. The following side effects are the ones most commonly reported for this group:

Abdominal pain
Coughing.
Diarrhea
Fatigue.
Fever.
Headaches.
Liver function test changes.
Low red blood cell counts.
Low platelet counts.
Nausea
Skin rash.
Swelling.
Vomiting

Please contact your doctor immediately if you experience any of the following additional side effects:

Abnormal heart rhythms.
Back pain
Chest pain.
Dizziness or lightheadedness.
Fainting.
Headache.
Increased blood pressure.
Itching.
Joint pain
Loss of appetite.
Respiratory tract infections
Seizures.

Bosulif can also cause problems with fertility in both male and female patients using the medication. Patients wishing to conceive a child in the future should discuss this risk with their doctor.

If you experience any of the above side effects ,  please consult your prescribing physician for additional information and other potential treatment options if using the medication becomes intolerable.

Can you chew, crush, or split Bosulif ?

Do not  crush, chew, or split this medication for any reason. Take Bosulif as a tablet, whole and undamage.

How effective is Bosulif?

Of the patients who use Bosulif for treatment during a study, between 47.2% and 77.2% of these individuals were found to have no cancer symptoms and no cancerous cells detected via bloodwork by the 12-month mark of treatment.

What are the ingredients in Bosulif?

The main and active ingredient in Bosulif is bosutinib monohydrate. The inactive ingredients in this medication are as follows: croscarmellose sodium, magnesium stearate, microcrystalline cellulose, poloxamer, polyethylene glycol, polyvinyl alcohol, povidone, talc, and titanium dioxide. The 100 mg and 400 mg tablets contain iron oxide yellow for coloring, and the 400 mg and 500 mg tablets contain iron oxide red for coloring.

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