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Giotrif is an oral medication prescribed to treat metastatic non-small cell lung cancer. It contains the active ingredient afatinib, which belongs to a class of drugs called kinase inhibitors. Afatinib binds to epidermal growth factor receptor (EGFR) in some tumors, slowing cell growth.

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Giotrif should be taken orally, typically once per day, as instructed by your doctor. It should be taken one hour before or two hours after eating. The prescribed dosage is dependent on the severity of your condition, your current medication schedule, and how you respond to treatment. Ensure you take this medication regularly to achieve the most benefit from it. It is helpful if you take it at the same time each day. Take Giotrif exactly as your doctor instructs you to. Do not take more than prescribed or for longer than recommended, as this will not improve your condition any faster and will increase your risk of side effects. Do not share this medication with anyone else, even if they have the same condition as you.

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This medication should be stored in its original packaging until it is time to take it. Store in a location that will not exceed 77 °F (25°C), out of direct sunlight and away from moisture. Avoid storing it in the bathroom. Keep out of reach of children and pets. Do not take expired or damaged products. Dispose of expired, surplus, or tampered-with products responsibly, following the instructions of your healthcare provider. Do not flush down the toilet or sink.

Side Effects

Common Side Effects

All medications come with a risk of side effects. It is important to recognize that your doctor has determined that your risk of side effects is outweighed by the potential benefit that this medication can provide. Side effects differ between individuals, and it is possible that you will not experience any at all. Side effects commonly associated with Giotrif are:

Mouth sores
Pain/redness/swelling of lips
Dry/itchy skin
Acne
Nose bleeds
Runny nose
Nausea/vomiting
Appetite loss
Diarrhea

If you experience any of these side effects and they worry you, or they worsen or do not resolve on their own, contact your healthcare provider.

Diarrhea is a very common side effect, and this can lead to dehydration. Ensure to drink plenty of fluid to compensate. Your doctor may prescribe anti-diarrhea medication to help your symptoms. If you experience symptoms of severe dehydration, such as severe or persistent diarrhea, abnormally infrequent or no urination, unusual dry mouth, very fast heartbeat, or severe lightheadedness, contact your healthcare provider.

Afatinib may commonly cause mild to moderate acneiform skin rashes. While it is usually harmless, it can be difficult to discern it from a rash associated with a severe reaction. Err on the side of caution and have any rash looked at by a doctor.

Severe Side Effects

Occasionally, Giotrif can be associated with severe side effects that should be taken seriously. Contact your doctor right away if you experience any of the following: vision changes, redness or pain in the eyes, changes in light sensitivity, discharge from the eyes, low potassium symptoms such as muscle cramps, weakness, or irregular heartbeat, bladder infection (burning sensation upon urination, urgency, or unusually frequent urination), or fingernail or toenail infection.

Seek emergency medical assistance immediately if you experience difficulty breathing, chest pain, swelling in your feet, abnormal fatigue, or unusual changes in weight. These can indicate serious lung problems or heart failure.

On rare occasions, afatinib can lead to liver disease or perforations in the gastrointestinal tract. These conditions can be fatal, so ensure to seek emergency medical assistance if you experience dark urine, nausea or vomiting that won’t stop, appetite loss, severe abdominal pain, or yellowing of the eyes or skin.

A severe allergic reaction to Giotrif is rare but not impossible. Seek medical help immediately if you experience allergic reaction symptoms such as rash, itching, facial swelling, dizziness, or difficulty breathing.

This is not an exhaustive list of side effects. If you notice any other abnormalities while taking this medication, contact your healthcare provider for assistance.

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