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Cotellic is an antineoplastic protein kinase inhibitor medication use for the treatment of metastatic melanoma, a type of skin cancer that is unable to be remove from the body with surgery and that has spread to other areas of the patient’s body. It is typically prescrib alongside the use of Zelboraf (vemurafenib).

This medication is only use for patients whose melanoma has been tested and come back positive for the specific genetic marker BRAF V600E or V600K.

How is Cotellic Use?

Cotellic is available as a tablet that should be taken orally, either with or without food, once daily for a duration of 21 days. The patient will then stop taking the medication for seven days and begin another round of 21-day treatment with Cotellic as instructed by their physician. Specific directions regarding the duration of treatment and method of taking Cotellic will be provided by the patient’s doctor.

Take this medication  at the same time each day without any missed doses for maximum efficacy. It should be taken exactly as instructed to provide the best possible treatment of the patient’s melanoma while avoiding increasing the risk of side effects associats with Cotellic.

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Cotellic should be store at room temperature and should not be expose to moisture or light.

Keep this medication out of the reach of children at all times.

Cotellic may be absorb through a person’s lungs and skin. Pregnant individuals or those who are trying to become pregnant should avoid handling Cotellic or breathing in any dust from Cotellic tablets.

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Cotellic is prescribed for the treatment of the type of skin cancer known as melanoma.

How Does Cotellic Work?

Cotellic is a kinase inhibitor that functions by inhibiting the growth and spread of mutated cells with abnormal MEK markers. Zelboraf, which is use alongside Cotellic, targets those cells associated with abnormal BRAF markers. Together, they effectively attack melanoma cells that are tied into both of these proteins, as treating only one of these types of cells would be ineffective.

The proteins MEK and BRAF are associates with cell growth. When there are abnormalities in these two proteins, such as in the case of cancer, the pairing of Cotellic and Zelboraf has proven to be effective at inhibiting the two proteins when mutated and reducing the growth and spread of cancer cells.

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Cotellic comes as a 20 mg tablet that you need to take once per day in a dosage of 60 mg (three tablets) at once.

This medication should be consume exactly as directed by the patient’s prescribing physician. In special circumstances, a patient’s doctor may give them a modified dosing schedule.

Overdose

If a patient has consumed too much Cotellic, they should contact their local Poison Control Center or seek out emergency medical attention. Patients that have consum an excessive amount of this medication may experience severe side effects as a result.

Side Effects

Cotellic has been associated with a variety of side effects ranging from common and mild symptoms to ones that require medical intervention.

The most common side effects of taking Cotellic are as follows:

Abdominal pain
Abnormal lab test results
Chills
Cold sores
Diarrhea
Dizziness
Dry mouth
Fever
Low sodium levels
Mouth sores
Sunlight sensitivity (i.e., easy sunburning)
Vomiting

What do I do if I missed a dose of Cotellic?

Patients that have missed a dose of Cotellic should simply skip the missed dose and take their next scheduled dose. Individuals taking Cotellic should never take additional doses or take doses too closely together to avoid significant adverse effects.

How long does Cotellic stay in your system?

Most patients have Cotellic leave their systems after two weeks have passed since their last dose.

What are the ingredients in Cotellic?

Cotellic tablets contain 22 mg of cobimetinib fumarate per 20 mg tablet. They will include inactive ingredients. The core of the tablet consists of magnesium stearate, croscarmellose sodium, lactose monohydrate, and microcrystalline cellulose. The coating of the 20 mg tablets consists of talc, polyethylene glycol, titanium dioxide, and polyvinyl alcohol.

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